184/18 | General Article | Veterinary Gynaecology and Obstetrics

Endometrial Healing and Recovery Rate Assessment with Bacterial Collagenase Therapy in Retained Fetal Membrane Cows

P.Mohan, K.Krishnakumar, K.Kulasekar, S.M.K.Karthickeyan and M.Murugan

Department of Veterinary Gynaecology and Obstetrics, Madras Veterinary College, TANUVAS, Chennai- 600 007, Tamil Nadu

Published in the Indian Veterinary Journal April 2019 : 96 (4) - pages 52 to 55
(Received: June, 2018, Accepted: November, 2018)


The retained fetal membrane (RFM) in cows presented to Obstetrics Unit, Madras Veterinary College, and Chennai within 12 to 24 h after parturition were utilized. Group I (n=7) cows with normal calving and shedding of placenta received one litre of normal saline intravenously as placebo treatment. Group II (n=15) unassisted calving RFM cows were treated with intrauterine proteolytic bolus containing nitrofurazone, metronidazole and urea and Inj. Streptopenicillin @ 20,000 units/ kg bwt., without manual removal for 7 days. Groups III unassisted calving RFM cows (n=l5) and Group IV (n=15) difficulty in parturition RFM cows, received single dose of 2,00,000 U of collagenase plus 40 mg of calcium chloride and 40 mg of sodium bicarbonate dissolved in one litre of normal saline at a pH of 7.5 intravenously through jugular vein. The lochial epithelial cell count was significantly (P<0.01) higher in group I on day 0 than the other groups; group III and IV did not differ significantly over group I on day 7 and 14 postpartum, however group II had significantly (P<0.01) decreased lochial epithelial cell count. The lochial leucocytic count was significantly (P<0.01) higher in group IV on day 0 and group II on day 7; however on day 14, it was similar to that of day 7 in all the groups. The overall mean concentration of lochial leucocytic count was significantly (P<0.01) higher in group II.

Key Words: RFM, bacterial collagenase recovery, Cows.

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