33/20 | Research Article | Veterinary Anatomy and Histology

Evaluation of serum biochemical, plasma catecholamine and serum cortisol in Delman horses with mild colic after various NSAIDs drug administration: A comparative study

Arya Pradana Wicaksono, Dodit Hendrawan, Muhammad Izzudin, Ali Ahmadi bin Ismail, Agus Purnomo, Shekhar Chhetri, and Muhammad Thohawi Elziyad Purnama

Department of Veterinary Anatomy, Faculty of Veterinary Medicine, School of Health and Life Sciences, Universitas Airlangga, Surabaya, Indonesia, 60115

Published in the Indian Veterinary Journal October 2022 : 99 (10) - pages 58 to 61
(Received: , Accepted: )


This study aimed to compare the administration of various NSAIDs drug on serum biochemistry, plasma catecholamines and serum cortisol in Delman horses associated with mild colic. A total of 32 horses were evaluated due to mild colic. Flunixin, ketoprofen, and phenylbutazone were administered intravenously at the recommended dose rates of 1.0; 2.2 and 4.4 mg/kg, respectively. Administration of the NSAIDs commenced on Day 1 and continued every 12 h for 12 days. Blood samples collected between days 2, 5, 9 and 13 to evaluate AST, ALP, GGT, creatinine, urea, epinephrine, norepinephrine, and cortisol level. The data analysis was performed using Multivariate analysis of variance (Manova) followed by Duncan multiple range test. The results showed a significant alleviation in all observed variables on Day 13, although the use of various NSAIDs showed no significant difference.

Key Words: serum biochemical, colic, NSAIDs, domesticated animals

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