27/19 | General Article | Veterinary Anatomy and Histology

Multivalent Dengue Vaccines and its Cellular Immune Response in New Zealand White Rabbit

LitaRakhma Yustinasari, Rahayu Ernawati, Fedik Abdul Rantam and Agus Widodo

Department of Veterinary Anatomy, Faculty of Vocational Study, Universitas Airlangga, Surabaya 60115, Indonesia

Published in the Indian Veterinary Journal June 2019 : 96 (6) - pages 37 to 38
(Received: January, 2019, Accepted: February, 2019)


A study was planned to investigate the role of multivalent dengue vaccines in rabbit cellular immune response. Eighteen rabbits were divided into three groups. P0 was injected with PBS as a control, P1 was vaccinated with 0.5 cc, and P2 was vaccinated with 0.3 cc and booster was done on day 14. Blood sample was collected on days 0, 7, 14, 21, and 28 for analysis of peripheral blood mononuclear cells (PBMCs) by immunouorescence. Rabbits vaccinated with multivalent dengue vaccines displayed signicantly higher numbers of TLR, CD4+ and CD8+ T cells (p<0.05) compared with the control. It was concluded that multivalent dengue vaccines could increase cellular immune response against DENV in rabbit.

Key Words: multivalent dengue vaccine, cellular immune response, TLR, T cells

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