52/20 | Clinical & Field Article | Veterinary Surgery and Radiology

Improved Biocompatibility of Gallium Silicon Titanium alloy for Biomedical Utilities

S.Tharani Kumar, M. Parthiban, Chandrasekaran Krithika and R.N. Raghavan

Dr MGR Educational and Research Institute University, Periyar E.V.R. High Road, Chennai 600095, Tamil Nadu

Published in the Indian Veterinary Journal March 2020: 97 (3) - pages 62 to 66
(Received: March, 2020, Accepted: May, 2020)


Assessment of Gallium Silicon Titanium alloy was done on their biocompatibility and cytotoxicity effect in vitro with SaoS2 cell line in terms of adhesion, viability, proliferation and mineralization on the surface of the alloys. quantitative results of cell adhesion with alamar blue dye containing media with cells on the alloy surface, absorbance measured at 570nm,600nm. Adhesion on the surface of alloy has shown 81.01%,71.20% and 87.31% respectively in GaSiTi, TiGa, and Ti alloys. The viability on the alloy was 55.70%, 60.37% and 65.03% respectively in GaSiTi, TiGa, and Ti alloys. The cell proliferation was found to be statistically insignicant between the groups which may pave way for the better mineralization. In mineralization the calcication in the alloys has progressively increased from day 4 today 21, the most ideal of (mean 92, S.D+/-1.54) has been achieved on day 8 itself indicating the effectiveness of the alloy. Qualitative results of cells on the surface of the alloys using scanning electron microscope were studied in this study

Key Words: Gallium Silicon Titanium Alloy, SaOS2Cell Line, Biocompatibility

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