220/22 | Research Article | Veterinary Pharmacology and Toxicology
Pharmacokinetic Study of Florfenicol Following Oral Administration in Broiler Poultry
Manisha Padaliya, A. H. Ahmad, Disha Pant, M. K. Verma, Swatilika, Deeksha Maletha and Aarti AdhikariDepartment of Veterinary Pharmacology and Toxicology, G. B. Pant University of Agriculture and Technology, Pantnagar, Uttarakhand.
Published in the Indian Veterinary Journal March 2023 : 100 (3) - pages 15 to 18(Received: , Accepted: )
Abstract
The pharmacokinetics of Florfenicol was studied in broilers following its oral administration @30 mg.kg-1b.w. Blood samples were taken at various time intervals and the concentration of Florfenicol in plasma was determined using high performance liquid chromatography (HPLC).The peak plasma concentration following Florfenicol administration at 1 hour was 3.314µg.ml-1.The calculated Cmax and Tmax were 3.130µg. mL-1 and 0.963 h, respectively. The distribution half-life(t1/2α) was 0.625 h and the elimination half-life (t1/2β) was 6.421 h. The mean area under the curve (AUC) was calculated as 13.352 µg.mL-1. Volume of distribution was (V/F) 7.934 L.kg-1 and the clearance from central compartment was (CL/F) 4.358 L.kg-1.h-1.Based on the study, an oral dosage regimen of Florfenicol with a priming dose of 6.94 mg.kg-1 with a maintenance dose of 3.864 mg.kg-1 at 8 h interval is recommended.
Key Words: Florfenicol, Broilers, Pharmacokinetics, HPLC, oral administration