70/19 | Clinical & Field Article | Veterinary Surgery and Radiology
The Antioxidant Activity of Pinus merkusii Ethanol Extract as Hepatoprotector in Mice
A.Herdiansyah, Rimayanti and S.A. SudjarwoFaculty of Veterinary Medicine, Airlangga University, Surabaya 60115, Indonesia
Published in the Indian Veterinary Journal October 2019 : 96 (10) - pages 60 to 62(Received: February, 2019, Accepted: July, 2019)
Abstract
This study was carried out to investigate the activity of the extract of Pinus merkusii in protecting against lead acetate-induced hepatotoxicity. Mice were given Pinus merkusii200 mg, 400 mg, and 800 mg/kg BW orallyonce in a day for 40 days, and on the 5thday, were given lead acetate 30 mg/kg BW one hour after Pinus merkusiiextract administration.Pinus merkusiiextracts significantly decreased the aspartate transaminase (AST), alanine transaminase (ALT), Malondialdehyde (MDA) levels and protected liver cell damage in lead acetate induced-hepatocyte. Pinus merkusii extract is a potent antioxidant and provide a promising hepatoprotective effect against lead acetate-induced hepatotoxicity
Key Words: Pinus merkusii extracts, MDA, lead acetate, hepatotoxicity