329/19 | General Article | Veterinary Pharmacology and Toxicology
Benecial Effect of Grinting Grass (Cynodon dactylon) on the Streptozotocin Induced Diabetes Mellitus in the MiceMartia Rani Tacharina, Arif Nur Muhammad Ansori, Hani Plumeriastuti, Kusnoto, Rochmah Kurnijasanti and Eka Pramyrtha Hestianah
Laboratory of Virology and Immunology, Department of Veterinary Microbiology, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, 60115, Indonesia.Published in the Indian Veterinary Journal April 2020: 97 (4) - pages 35 to 38
(Received: September, 2019, Accepted: October, 2019)
The aim of this study was to investigate antidiabetic activity of the non-polisacharide fraction of the aquoeus extract of grinting grass (NPF-GG) in streptozotocin induced diabetes in mice. Thirty male BALB/C mice of two months age were divided into ve groups: placebo control, metformin control, NPF-GG treated groups(250 mg/kgBW, 500 mg/kgBW, and 1000 mg/kgBW, respectively).Hypoglicemic effect and histopathological features of the pancreatic islet showed that NPF-GG have high antidiabetic effect.It induced hypoglicemic effect and increased the cell quantity in Langerhans cells in the pancreasKey Words: antihyperglicemic activity, Cynodon dactylon, diabetes mellitus, pancreatic islet.