345/19 | General Article | Veterinary Clinical Medicine
Hepato-protective Effect of the Red Dragon Fruit (Hylocereuspolyrhizus) Ethanol Extract in Hypercholesterolemic Mice (Mus musculus)
Djoko Legowo, Hani Plumeriastuti, Arimbi, and LitaRakhma YustinasariDepartment of Pathology, Faculty of Veterinary Medicine, UniversitasAirlangga, JalanMulyorejo C Campus, Surabaya 60115, Indonesia
Published in the Indian Veterinary Journal May 2020: 97 (5) - pages 30 to 33(Received: September, 2019, Accepted: February, 2020)
Abstract
This study was conducted to investigate the effect of red dragon fruit ethanol extract on the liver of hypercholesterolemic mice.Thirty mice were divided into five groups: C(-) as negative control group; C(+) as hypercholesterolemic group; T1, T2, and T3 were hypercholesterolemic groups treated with red dragon fruit ethanol extract (5mg/20g bw; 10mg/20g bw; 20mg/20g bw respectively). The experiment was conducted for four weeks.The histopathological changes in the liver were scored. All the treatment groups displayed significantly different (p<0.05) histopathological changes in the liver compared to the hypercholesterolemic group. It was concluded that the red dragon fruit ethanol extract has the potential to decrease the degree of the liver damage in the hypercholesterolemic mice.
Key Words: red dragon fruit, hypercholesterolemia, mice, liver