239/22 | Research Article | Veterinary Surgery and Radiology

Effect of BisphenolA on Hearts of Pregnant Mice and Their Fetuses

Raghad A. Najjar, Firas M. Abed, and Rayya G. Alsultan

Department of Biology, College of Education for Pure Science, University of Mosul, Mosul, Iraq

Published in the Indian Veterinary Journal December 2022 : 99 (12) - pages 27 to 34
(Received: , Accepted: )


The current study wasaimed to identify the effect of Bisphenol A on the histology of hearts in mice during pregnancy. Thirty pregnant mice were used for the study and were divided into three groups of ten each, the first one being control group. Mice in the second and third group were given Bisphenol A orally from the sixth to eighteenth day of pregnancy. Both groups received different concentrations of Bisphenol: second group 300mg/kg and third group 450mg/kg concentration.Mice in the second group showed many histological lesions, including numerous small to moderately sized regions of myocardial degeneration and necrosis. Myocardial fibers lost the cross striations and the nuclei were not visible. There were several extensive areas of loss or separation of myofibers characterized by increased edema. A few minor marinating neutrophilic inflammatory cells were seen. In contrast, mice in the third group showed myocardial necrosis and fibrin deposits between myocytes fibers. Signs of interstitial edema with significant disorganized myocardial fibers were seen. There was thickening of blood vessels accompanied by endothelial cell necrosis. An acute stage of myofiber necrosis is characterized by the presence of hyaline, and cytoplasmic eosinophilia of cardiomyocytes. Several areas of the heart showed cardiomyocytes with an enlarged nucleus; Fibrin thrombi and perivascular fibrosis were observed. There was endothelial cell swelling some of which were separated from the basement me

Key Words: bisphenol A; heart; pregnant mice

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