Research Article | Animal Biotechnology

In Silico Evaluation of Selected Flavonoids as Neuraminidase Inhibitors : Hope for the Discovery of Anti-Avian Influenza Virus Compounds

Hardeep Singh Tuli, Zahoor Abbas, Gurpreet KaurBhatia, Shweta, Shanoo Sharma, Kuldeep Dhama, KhanSharun, Manoj Kumar and Pawan Kumar

Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, 133207, India

Published in the Indian Veterinary Journal May 2021 : 98 (5) - pages 18 to 23
(Received: , Accepted: )


Flavonoids are one among the categories of plant bioactive metabolites with promising therapeutic applicability. The motive of this study was to investigate possible molecular interactions of selected flavonoids (Apigenin, Kaempferol, and Quercetin) with neuraminidase receptor (PDB ID:2HU0) protein of flu virus. Pyrxmolecular docking software was used to find possible binding interactions between ligand and receptor. Biovia discovery studio visualizer was used to analyze the molecular docking results. Results of current investigation uncovered that selected plant metabolites have interacted with targeted neuraminidase receptor protein with energy minimization in the range of -6.7to -8.2Kcal/mol.

Key Words: Molecular docking, Apigenin, Kaempferol, Quercetin and Neuraminidase

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