251/19 | General Article | Veterinary Surgery and Radiology

Nano Spray Inhaler Ashitaba Leaf Extract (Angelica keiskei) on Malondialdehyde, Catalase Enzyme Activity and Lung Tissue Damage in Mice Exposed to Cigarette Smoke

Akhmad Afifudin Al-Anshori, Diah Ayu Retanti, Indah Trilestari, Lilik Maslachah and Hani Plumeriastuti

Department of Basic Veterinary Medicine, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia 60116

Published in the Indian Veterinary Journal November 2019 : 96 (11) - pages 58 to 61
(Received: July, 2019, Accepted: July, 2019)


A total of 30 mice were divided into 5 treatment groups. K1: control (-) group not exposed to cigarette smoke and not given nanospray inhalers. K2: control (+) group exposed to cigarette smoke and not given nanospray inhalers. P1, P2, and P3 The treatment group exposed to cigarette smoke for 28 days and given nanospray inhaler asitaba leaf extract (Angelica keiskei) at a dose of 50 g / KgBB / day, 200 g / KgBB / day and 500 g / KgBB /day. Day 29 was given nanospray inhalers for 3 weeks, then Malondialdehyde (MDA), enzyme catalase activity ware examined from serum and lung organs for pulmonary histopathology. The administration of 200 g / KgBB / day nanospray inhaler can reduce malondialdehyde levels, activation of the enzyme catalase, emphysema, inammatory cell inltration and the number of erythrocytes exposed to cigarette smoke.

Key Words: Nano Spray Inhaler, Ashitaba Leaf Extract (Angelica keiskei), pulmonary histopathology.

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