378/18 | General Article | Veterinary Surgery and Radiology
Non Steroidal Anti-Inammatory (NSAIDs) Drugs on Cardiopulmonary Functions During General Anaesthetic Protocol in Dogs
R.Manikandan, S.Dharmaceelan, K.Jayakumar, S.Senthilkumar and P.SelvarajDepartment of Veterinary Surgery and Radiology, Veterinary College and Research Institute (TANUVAS), Namakkal-637 001, Tamilnadu
Published in the Indian Veterinary Journal May 2019 : 96 (5) - pages 34 to 37(Received: October, 2018, Accepted: December, 2018)
Abstract
A clinical study was conducted in 24 dogs to compare the cardiopulmonary and isourane sparing effects on inclusion of meloxicam, ketoprofen, tolfenamic acid and unixin in general anaesthetic protocol of dogs. Meloxicam, ketoprofen, tolfenamic acid and unixin were administered @ 0.2, 2.0, 4.0 and 1.0 mg per kg i.v.in group I, II, III and IV animals, respectively. Midazolam was administered @ 0.3 mg per kg i.v. to all the animals. General anaesthesia was induced with propofol @ 6 mg/kg i.v. in all the animals and maintained with isourane. Ovariohysterectomy (OHE) was performed as per the standard technique. The tidal volume (VT), minute volume (VE), saturation of peripheral oxygen (SpO2), mean arterial pressure (MAP) and electrocardiography (ECG) were recorded. Fraction of inspired-oxygen, end-tidal oxygen, fraction of inspired-carbon dioxide, end-tidal carbon dioxide, fraction of inspired-isourane and end-tidal isourane concentration were also recorded continuously during maintenance of anaesthesia. The postoperative analgesic efcacy of meloxicam and ketoprofen was found superior than tolfenamic acid and unixin. No major alterations in cardiopulmonary functions were noticed by the inclusion of NSAIDs in the anaesthetic protocol of dogs. Meloxicam had a signicant isourane sparing effect than other drugs.
Key Words: Cardiopulmonary effect, Anti in ammatory drugs, General anaesthesia, Dogs