378/18 | General Article | Veterinary Surgery and Radiology

Non Steroidal Anti-Inammatory (NSAIDs) Drugs on Cardiopulmonary Functions During General Anaesthetic Protocol in Dogs

R.Manikandan, S.Dharmaceelan, K.Jayakumar, S.Senthilkumar and P.Selvaraj

Department of Veterinary Surgery and Radiology, Veterinary College and Research Institute (TANUVAS), Namakkal-637 001, Tamilnadu

Published in the Indian Veterinary Journal May 2019 : 96 (5) - pages 34 to 37
(Received: October, 2018, Accepted: December, 2018)


A clinical study was conducted in 24 dogs to compare the cardiopulmonary and isourane sparing effects on inclusion of meloxicam, ketoprofen, tolfenamic acid and unixin in general anaesthetic protocol of dogs. Meloxicam, ketoprofen, tolfenamic acid and unixin were administered @ 0.2, 2.0, 4.0 and 1.0 mg per kg i.v.in group I, II, III and IV animals, respectively. Midazolam was administered @ 0.3 mg per kg i.v. to all the animals. General anaesthesia was induced with propofol @ 6 mg/kg i.v. in all the animals and maintained with isourane. Ovariohysterectomy (OHE) was performed as per the standard technique. The tidal volume (VT), minute volume (VE), saturation of peripheral oxygen (SpO2), mean arterial pressure (MAP) and electrocardiography (ECG) were recorded. Fraction of inspired-oxygen, end-tidal oxygen, fraction of inspired-carbon dioxide, end-tidal carbon dioxide, fraction of inspired-isourane and end-tidal isourane concentration were also recorded continuously during maintenance of anaesthesia. The postoperative analgesic efcacy of meloxicam and ketoprofen was found superior than tolfenamic acid and unixin. No major alterations in cardiopulmonary functions were noticed by the inclusion of NSAIDs in the anaesthetic protocol of dogs. Meloxicam had a signicant isourane sparing effect than other drugs.

Key Words: Cardiopulmonary effect, Anti in ammatory drugs, General anaesthesia, Dogs

Main Article

Access to the IVJ Digital Archives is restricted to our paid subscribers. Please consider becoming a subscriber to continue reading this article.