04/19 | General Article | Veterinary Surgery and Radiology

RUNX2 and SOX9 Expression on Chondrocyte Hypertrophy Formation in Post-Menopausal Osteoarthritis Mechanism (An Experimentation on Rat Model)

Bimo Sasono, Heri Suroto, Dwikora N. Utomo, Aulani Am, Hari Basuki N, Damayanti Tinduh and Fedik A. Rantam

Stem Cells Research and Development Center, Laboratory of Virology and Immunology, Microbiology Department, Faculty of Veterinary Medicine Airlangga University, Indonesia

Published in the Indian Veterinary Journal October 2019 : 96 (10) - pages 41 to 44
(Received: January, 2019, Accepted: May, 2019)


In osteoarthritis post-menopause, decreasing estrogen inuenced formation of chondrocyte hypertrophy. This study would explain role of RUNX2 and SOX9 to chondrocyte hypertrophy formation in decreasing estrogen condition. Fifty four rats were divided into six groups. Level of 17 β estradiol and TGF-β were examined by ELISA. SOX9 and RUNX2 used immunohistochemistry. Histopathology for chondrocyte hypertrophy. Level of 17 β estradiol and SOX9 on treatment group decreased signicantly, TGF-β and RUNX2 increased signicantly. Chondrocyte hypertrophy increased signicantly in treatment group. The decreasing of 17 β estradiol level caused increasing hypertrophy Chondrocyte through increasing level of TGF-β and RUNX2.

Key Words: Chondrocyte hypertrophy, Estrogen, RUNX2, TGF-β.

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