136/19 | General Article | Stem Cell Research and Regenerative Medicine
Eyelid Occlusion induced Form Deprivation Myopia (FDM) on Axial Length and Morphological Changes of the Sclera in RabbitsRini Kusumawardhany, GatutSuhendro, Tjahjono D. Gondhowiardjo, Nurwasis, AtinaYustisia Lestari and LitaRakhmaYustinasari
Department of Ophthalmology, Medical Faculty, WijayaKusuma University, Surabaya, Jalan Dukuh Kupang XXV, no. 54, Surabaya 60225, East Java, IndonesiaPublished in the Indian Veterinary Journal October 2019 : 96 (10) - pages 38 to 40
(Received: April, 2019, Accepted: May, 2019)
The aim of the research was to induce form deprivation myopia (FDM) and to investigate the axial length and morphological changes of the sclera. Eight rabbits were monocularly deprived by occlusion the right eyelids for 4 weeks as (FDM group): the left eye served as an untreated contralateral control group. Axial length was measured by A-scan biometry. The scleral thickness and scleral broblast were evaluated by light microscopy. Statistical analysis using a paired t-test showed that axial length post-treatment (p =0.004) in FDM group was signicantly longer than those of the contralateral eyes. Signicant reduction in the scleral thickness (p<0.000) and the scleral broblast (p<0.001) was noticed in FDM group compared with the control. In conclusion, eyelid occlusion could be validated to induce form-deprivation myopia model in rabbit and the sclera plays an important role in the induction of myopiaKey Words: Eyelid occlusion deprivation myopia, rabbit.