136/19 | General Article | Stem Cell Research and Regenerative Medicine

Eyelid Occlusion induced Form Deprivation Myopia (FDM) on Axial Length and Morphological Changes of the Sclera in Rabbits

Department of Ophthalmology, Medical Faculty, WijayaKusuma University, Surabaya, Jalan Dukuh Kupang XXV, no. 54, Surabaya 60225, East Java, Indonesia

Abstract

The aim of the research was to induce form deprivation myopia (FDM) and to investigate the axial length and morphological changes of the sclera. Eight rabbits were monocularly deprived by occlusion the right eyelids for 4 weeks as (FDM group): the left eye served as an untreated contralateral control group. Axial length was measured by A-scan biometry. The scleral thickness and scleral  broblast were evaluated by light microscopy. Statistical analysis using a paired t-test showed that axial length post-treatment (p =0.004) in FDM group was signicantly longer than those of the contralateral eyes. Signicant reduction in the scleral thickness (p<0.000) and the scleral broblast (p<0.001) was noticed in FDM group compared with the control. In conclusion, eyelid occlusion could be validated to induce form-deprivation myopia model in rabbit and the sclera plays an important role in the induction of myopia

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