General Article | Animal Biotechnology

Role of Sox18 Protein in 2, 4-D and Endotoxin Induced Lung Damage Progression in Mice

College of Animal Biotechnology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana

Abstract

Pesticides are widely used in agricultural industry to protect crops from pests and weeds, but due they are also a threat to environment and non-target species. The study was designed to determine the molecular mechanism behind 2,4-D and endotoxin induced lung toxicity. Mice lung samples were collected following chronic exposure to high (37mg/kg) and low (18.5mg/kg) of 2, 4-D. Global view of differentially expressed genes showed increased expression of Sox 18 gene by 1.86, 1.95, 2.10 and 1.79 folds following exposure to high dose alone and in combination of LPS and low dose alone in combination of LPS. Increased expression of Sox 18 could serve as putative target or indicator of pesticide induced lung damage.

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