301/19 | Clinical & Field Article | Stem Cell Research and Regenerative Medicine

The Protective effect of Swietenia macrophylla Extract Nanoparticles on Pulmonary Damage in Streptozotocin-Induced Diabetic Rats

S.A. Sudjarwo and G. Wardani

Faculty of Veterinary Medicine, Airlangga University, Surabaya 60115, Indonesia

Published in the Indian Veterinary Journal December 2019 : 96 (12) - pages 54 to 56
(Received: August, 2019, Accepted: October, 2019)


This study was conducted to investigate the effect of the Swietenia macrophylla nanoparticles in protecting pulmonary damage on a diabetic rat. Rats were given Swietenia macrophylla nanoparticles 100 mg, 200 mg, and 400 mg/kg BW orally once in a day for 40 days, and on 3rd day were given Streptozotocin 60 mg/kg BW a single dose intraperitoneally, one hour after Swietenia macrophylla nanoparticles administration. Swietenia macrophylla nanoparticles signicantly decreased both blood glucose and Malondialdehyde (MDA) levels, increased plasma insulin and protected pulmonary cell damage on streptozotocin induced-diabetic rat. Swietenia macrophylla nanoparticles have a potent antioxidant and anti-diabetic effect which can provide a protection on pulmonary damage in diabetic rat

Key Words: Swietenia macrophylla, Malondialdehyde, pulmonary damage, rats

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