301/19 | Clinical & Field Article | Stem Cell Research and Regenerative Medicine
The Protective effect of Swietenia macrophylla Extract Nanoparticles on Pulmonary Damage in Streptozotocin-Induced Diabetic Rats
S.A. Sudjarwo and G. WardaniFaculty of Veterinary Medicine, Airlangga University, Surabaya 60115, Indonesia
Published in the Indian Veterinary Journal December 2019 : 96 (12) - pages 54 to 56(Received: August, 2019, Accepted: October, 2019)
Abstract
This study was conducted to investigate the effect of the Swietenia macrophylla nanoparticles in protecting pulmonary damage on a diabetic rat. Rats were given Swietenia macrophylla nanoparticles 100 mg, 200 mg, and 400 mg/kg BW orally once in a day for 40 days, and on 3rd day were given Streptozotocin 60 mg/kg BW a single dose intraperitoneally, one hour after Swietenia macrophylla nanoparticles administration. Swietenia macrophylla nanoparticles signicantly decreased both blood glucose and Malondialdehyde (MDA) levels, increased plasma insulin and protected pulmonary cell damage on streptozotocin induced-diabetic rat. Swietenia macrophylla nanoparticles have a potent antioxidant and anti-diabetic effect which can provide a protection on pulmonary damage in diabetic rat
Key Words: Swietenia macrophylla, Malondialdehyde, pulmonary damage, rats