126/22 | Research Article | Veterinary Surgery and Radiology

Histopathological Impact of Acetaminophen on Liver of Nile Tilapia

Department of Zoology, Maharaja’s College Ernakulam, Kerala 682011, India

Abstract

This study is conducted to assess the histopathological effect of acetaminophen (paracetamol) on the histology of the liver of Nile Tilapia. The fishes were exposed to sub-lethal concentrations (1/10th and 1/5thof LC50 value) of paracetamol for 96 hours. A control was run along with it. The results indicate that the acetaminophen causes hepatotoxicity in experimental fish. The liver showed congestion and necrosis. The effect of acetaminophen on liver tissues increased with dose and duration of exposure. Fishes exposed to 1/5th of LC50 value of paracetamol showed more tissue damage in the liver, compared to the fish exposed to 1/10th of LC50 value of paracetamol. Study reveals that drug-induced hepatic injury has become a major challenge. .

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