267/22 | Research Article | Veterinary Pathology

Coronary Artery Wall Thickness and Lumen Diameter of Nicotine-Induced White Rats (Rattus norvegicus)

Nur Anisah, Maya Nurwartanti Yunita, Hani Plumeriastuti, Bodhi Agustono, and Reina Puspita Rahmaniar

Division of Pathology Veteriner, School of Health and Life Sciences (SIKIA), Universitas Airlangga, Surabaya, Indonesia.

Published in the Indian Veterinary Journal April 2023 : 100 (4) - pages 15 to 18
(Received: , Accepted: )


Nicotine can cause hemodynamic disorders for good health. This study aimed to observe the histopathology of lumen diameter and coronary artery wall thickness in white rats exposed to nicotine. Rats were divided into five treatment groups, C (without nicotine exposure), T1,T2,T3, and T4 (nicotine concentration 0,005mg/ml; 0,05mg/ml; 0,2mg /ml, and 0.65 mg/ml). The results showed a significant difference in coronary artery wall thickness between the control and treatment groups. The diameter of the coronary artery lumen was narrowed. In conclusion, a higher concentration of nicotine can increase the thickness of the coronary artery wall and decrease the lumen diameter.

Key Words: coronary artery, good health, histopathology, nicotine, white rats

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