02/22 | Research Article | Veterinary Biochemistry
Protective Action of Lactoferrin and Dexamethasone Sodium in Ulcerative Colitis in Rats
Lavudya Naveen, Ashok Kumar Devarasetti, Akkaldevi Jayasri, Alla Gopala Reddy, Banoth Anil Kumar and Mohammed Shaz MurtuzaDepartment of Veterinary Biochemistry, Faculty of Veterinary Sciences, College of Veterinary Science, Rajendranagar - 500030, PVNRTVU, Hyderabad.
Published in the Indian Veterinary Journal February 2021: 98 (2) - pages 20 to 24(Received: January, 2022, Accepted: February, 2022)
Abstract
Lactoferrin (Lf), a member of transferrin family, is an iron-binding glycoprotein present in exocrine secretions and has various defensive functions. The present study was aimed to evaluate the anti-inflammatory and healing property of lactoferrin when administered orally (200 mg/kg b.wt.) in acetic acid-induced colitis (4%, 2ml intra-colonic) in rats. Colitis index studies revealed that administration of lactoferrin and dexamethasone sodium for 14 days significantly changes colon length and weight caused by acetic acid induced colitis, suggesting that lactoferrin has an anti-inflammatory and healing effect on acetic acid induced colitis in rats. Therefore, lactoferrin may be a potential therapeutic agent for the treatment of colitis.
Key Words: Lactoferrin, Dexamethasone Sodium, Acetic acid and colitis index