36/19 | General Article | Veterinary Anatomy and Histology
Protective Effect of Polygonum minus Leaves Ethanol Extract on Cadmium Chlorideinduced Alteration of Aortic Histopathology in Mice (Mus musculus)
Putri Anggraheni Kusumaningrum, Lita Rakhma Yustinasari, Iwan Syahrial Hamid, Sri Agus Sudjarwo, Kuncoro Puguh Santoso, Chairul Anwar and Agus WidodoVeterinary Anatomy Department, Faculty of Veterinary Medicine, Universitas Airlangga Jl. Mulyorejo, Surabaya, East Java, Indonesia 60115.
Published in the Indian Veterinary Journal July, 2019 : 96 (7) - pages 39 to 42(Received: January, 2019, Accepted: March, 2019)
Abstract
This study was conducted to investigate the effect of Polygonum minus leaves ethanol extract on histopathological changes in aortic wall of mice induced by cadmium chloride. Thirty male mice were divided into ve groups and were administered via intragastric gavage for 21 days. Treatments were negative control (CMC Na 0.5% solution + aquadest), positive control (CMC Na 0.5% solution + 12 mg/kg bw of cadmium chloride), T1, T2, and T3 (200, 400, and 800 mg/kg bw of Polygonum minus leaves extract respectively + 12 mg/kg bw of cadmium chloride). Mice treated with Polygonum minus leaves ethanol extract 400 and 800 mg/kg bw displayed signicantly reduced aortic wall damage (p<0.05) compared with positive control. Thus the present ndings suggest that Polygonum minus leaves ethanol extract could protect aortic wall against cadmium chloride exposure in mice
Key Words: Polygonum minus, cadmium chloride, Mus musculus, aorta