294/19 | General Article | Wild Life Sciences

Adjuvant Therapy of Syzygium cumini Leaf and Fruit Extract Nanoparticles in Mice (Mus musculus) Infected by Plasmodium berghei

Lilik Maslachah, Rahmi Sugihartuti, Retno Sri Wahjuni and Lita RakhmaYustinasari

Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya 60116, Indonesia

Published in the Indian Veterinary Journal February 2020: 97 (2) - pages 33 to 36
(Received: August, 2019, Accepted: October, 2019)


The aim was determine the efcacy of Syzygium cumini leaf and fruit extracts nanoparticles to mice infected with Plasmodium berghei at 1x105 of Plasmodium berghei. Treatment was given 24 hours post infection for 4 days. Observed from the 5th day to 12th day post infection. The results of per cent parasitemia, growth inhibition, Parasite Clearance Time, and Recrudescence Time of parasites. Syzygium cumini fruit nanoparticles with chloroquine were better than Syzygium cumini leaf nanoparticles with chloroquine, whereas the Survival time, Hb content, splenic index and liver index were same. Efcacy of Syzygium cumini leaf and fruit extracts nanoparticles increased when used as an adjuvant therapy with chloroquin in mice infected by Plasmodium berghei.

Key Words: Nanoparticle, Syzygium cumini, Plasmodium berghei, Therapy

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