372/19 | Research Article | Veterinary Clinical Medicine

Effects of Tithonia diversifolia on blood glucose levels, renal and pancreatic histopathology of Wistar rats: A model of diabetic nephropathy

Iwan Sahrial Hamid, Faisal Fikri, Muhammad Thohawi Elziyad Purnama, Rondius Solfaine, and Shekhar Chhetri

Department of Veterinary Physiology, Pharmacology, and Anatomy, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya 60115, Indonesia

Published in the Indian Veterinary Journal November 2022 : 99 (11) - pages 37 to 39
(Received: , Accepted: )


This study was aimed to determine the effect of Tithonia diversifolia as an antidiabetic agent on blood glucose levels and renal and pancreatic histopathology of Wistar rats. A total of 24 Wistar rats were divided into three treatment groups i.e., (C-) no treatment, (C+) induced diabetic nephropathy, (T1) induced diabetic nephropathy and given ethanolic extract of T. diversifolia. The results showed that in T1 group, post-treatment blood glucose levels decreased significantly (p<0.05). Renal and pancreatic histopathology of rats in this group showed that necrosis and inflammation of cells decreased significantly (p<0.05). It can be concluded that T. diversifolia has antidiabetic effects and reduce blood glucose levels and also reduce inflammation of renal and pancreatic cells in diabetic nephropathy induced Wistar rats.

Key Words: Tithonia diversifolia, diabetic nephropathy, antidiabetic, diabetes

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