400/19 | General Article | Veterinary Physiology

Role of Superoxide Dismutase (SOD) and Glutathione Peroxidase (GPx) Expression of Xanthone as Protector on 2-methoxyethanol (2-ME)- Induced Leydig Cell Oxidative Damage

Ernawati, R. I’tishom and S.A. Sudjarwo

Faculty of Medicine, Airlangga University, Surabaya 60115, Indonesia

Published in the Indian Veterinary Journal May 2020: 97 (5) - pages 15 to 18
(Received: November, 2019, Accepted: January, 2020)


The purpose of this research was to determine the protective effect of xanthone on 2-methoxyethanol (2-ME)-induced Leydig cell damage. The mice were given the xanthone 60 mg, 120 mg, and 240 mg/kg BW orally once in a day for 38 days, and on the 3rd day, they were given 2-ME 200 mg/kg BW one hour after the xanthone administration. The administration of xanthone significantly increased the expression of superoxide dismutase (SOD) and glutathione peroxidase (GPx) on Leydig cell. Xanthone also significantly increased Leydig cell number, it is concluded that the xanthone could be a potent antioxidant and have a promising protective effect against 2-ME-induced Leydig cell damage

Key Words: Antioxidant, Xanthone, Leydig cell, Oxidative stress

Main Article

Access to the IVJ Digital Archives is restricted to our paid subscribers. Please consider becoming a subscriber to continue reading this article.