244/19 | General Article | Livestock Production Management

Antiangiogenesis Activity of Centella Asiatica on the Macrophage Number and Matrix Metalloproteinase-9 in Blood Vessels of Chorioallantois Membrane Induced by Basic Fibroblast Growth Factor

Iwan Sahrial Hamid

Department of Veterinary Pharmacology, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya 60115, Indonesia.

Published in the Indian Veterinary Journal February 2020: 97 (2) - pages 17 to 20
(Received: June, 2019, Accepted: September, 2019)


This study aimed to examine the potential of aqueous extract of Centella asiatica on the macrophage number and matrix metalloproteinase-9 (MMP-9) in blood vessels of chorioallantois membrane induced by basic Fibroblast Growth Factor (bFGF). This study used 20 embryonated chicken eggs (ECE) which were divided into  ve groups i.e. positive control (C+) given 60 ng of bFGF; negative control (C-) given DMSO 2%; treatment groups (T1; T2; T3) given 60 ng of bFGF and Centella asiatica extract (75; 90; 110) μg. It was concluded that Centella asiatica at a dose of 110 μg decreased the macrophage number and the expression of MMP-9

Key Words: Centella asiatica, Chorioallantois membrane, Macrophage, MMP-9

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