255/19 | General Article | Veterinary Gynaecology and Obstetrics

Effect of Polysaccharide Krestin on MMP3 Expression and Foot Diameter in Rheumatoid Arthritis in Rat

Diah Purwaningsari, Jusak Nugraha, Sri Puji Astuti Wahyuningsih, Suhailah Hayaza, Raden Joko Kuncoroningrat Susilo and Win Darmanto

Department of Biology and Department of Medicine,Universitas Airlangga, Surabaya 60115, Indonesia.

Published in the Indian Veterinary Journal January 2020: 97 (1) - pages 24 to 26
(Received: July, 2019, Accepted: September, 2019)


The present study was carried out to elucidate effect of Polysaccharide krestin (PSK) in treating rheumatoid arthritis (RA). Wistar male rats (Rattus norvegicus) (60) were divided into six groups. Measurement of MMP3 expression was done by using immunohistochemical methods and foot diameter was measured using calipers. The results showed a signicant difference decrease in the treatment groups in MMP3 concentration and foot diameter

Key Words: Polysaccharide Krestin (PSK), Rheumatoid Arthritis, Rat

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