349/19 | General Article | Veterinary Physiology
Assessment of Cisplatin-Induced Kidney Injury Through Histopathological Changes in Mouse Models
Djoko Santoso, I Ketut Sudiana, Anny Setijo Rahayu and Muchammad YunusDepartment of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Indonesia.
Published in the Indian Veterinary Journal May 2020: 97 (5) - pages 44 to 46(Received: November, 2019, Accepted: January, 2020)
Abstract
The purpose of the study is to assesst cisplatininduced kidney injury on cancer therapy through histopathological changes in mouse models. Group 1 served as the control group and received normal saline intraperitoneally (25 ml/kg). Group 2 was injected intraperitoneally cisplatin in a single dose of 25 mg/kg. Seventy two hours after cisplatin injection, all mice of both groups were sacrificed to exam the kidneys histopathological changes. There was no kidney injury histologically showed normal architecture of the glomerulus and tubules in control mice, while in cisplatin injected mice group, kidney injury histologically first marked with mononuclear cell infiltration, glomerular congestion, tubular necrosis and hyaline casts in the tubular lumen
Key Words: cisplatin, histological kidney injury, mouse model.