Research Article | Veterinary Pharmacology and Toxicology

Hepatoprotective activity of Chenopodium album against cyclophosphamide-induced hepatotoxicity in rats

Manish Kumar Verma, Abul Hassan Ahmad, Satya Pal Singh, Disha Pant, Neeraj Kumar and Javid Ur Rahman

Department of Veterinary Pharmacology and Toxicology, College of Veterinary & Animal Sciences, Govind Ballabh Pant University of Agriculture and Technology, Pantnagar, Uttarakhand, India–263145

Published in the Indian Veterinary Journal June 2022 : 99 (6) - pages 25 to 29
(Received: , Accepted: )


Chenopodium album belongs to the family Chenopodiaceae. Chenopodium encompasses 120 species. It is found worldwide, especially in North America, India, and Europe. It is a commonly cultivated important food crop and medicinal plant, widely used worldwide for food and traditional herbal medicine in tropical and subtropical countries. Chenopodium album is a rich source of several components such as minerals, vitamins, essential fatty acids, alkaloids and flavonoids. However, the hepatoprotective efficacy of Chenopodium album leaf extract against hepatotoxicity caused by cyclophosphamide in albino rats was evaluated.In this study, several hepatoprotective markers were examined in the serum of healthy and hepatotoxic rats, such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and total protein (TP). A histopathological examination was also performed on the tissues of the rat liver. Rats treated with leaf extracts showed significant reduction in ALP, AST, ALT and total proteins were found retrieving towards normalcy. Hepatoprotective action was also proven. From the results, it can be concluded that the Chenopodium album possesses hepatoprotective action against cyclophosphamide-induced hepatic toxicity in rats.

Key Words: Cyclophosphamide, Hepatoprotective, Chenopodium album

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