Research Article | Animal Biotechnology

Effect of Cardiopulmonary Bypass on Dynamic Lung Compliance in Isoflurane Anesthetized Sheep

Division of In-vivo Models and Testing, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India. 695012

Abstract

Aim of the study was to compare the dynamic lungcompliance (DLC) before and after cardiopulmonary bypass in sheep anesthetized using isoflurane. Six healthy sheep subjected to right ventricular outflow tract substitution with valved conduit were the animals for study. There was a reduction in the DLC soon after the bypass procedure and a more reduction was observed after closure of thoracotomy incision while weaning. The decrease in value of DLC after bypass procedure while weaning was significantly different compared to the value before thoracotomy. The study concluded that cardiopulmonary bypass procedure in sheep anesthetized with isoflurane significantly decreased DLC compared to before thoracotomy.

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