249/19 | General Article | Veterinary Microbiology

Immunomodulatory Activity of Black Jinten Oil (Nigella sativa) as Macrophage Activator for Salmonella typimurium Infected Rat

Dewa K. Meles, Erma Safitri, Wurlina, Imam Mustofa, Suherni Susilowati and Desak K.S.C. Putri

Veterinary Medicine Faculty, Universitas Airlangga, Surabaya 60115, Indonesia.

Published in the Indian Veterinary Journal January 2020: 97 (1) - pages 12 to 14
(Received: July, 2019, Accepted: September, 2019)


This study was aimed to prove immunomodulatory activity of Nigella sativa as macrophage activator for S.typimurium infected rats. 125 rats were divided into ve groups and observed for ve days (2nd, 4th, 6th, 8th, 10th). The rats were infected with S.typimurium 105CFU by intraperitoneal route, and given black jinten oil doses 12.60 mg, 18.90 mg, 25.20mg/200 gram bw/day, for 10 days. The observation: total number of leukocytes, neutrophils, eosinophils, basophils, lymphocytes, monocytes, activated macrophages. The results showed that black jinten oil was able to maintain an immune response towards normal total number of leukocytes and activated macrophages, in rats which were infected with S.typhimurium

Key Words: Black jinten oil, Immunomodulators, Salmonellosis

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