56/19 | General Article | Animal Genetics and Breeding

Epitopes Prediction According to Glycoprotein Encoding Gene of Rabies Virus Local Isolates as Vaccine Candidate against Circulating Rabies Virus in Indonesia

JolaRahmahani, Suwarno and Fedik Abdul Rantam

Laboratory of Virology and Immunology, Department of Veterinary Microbiology, Faculty of Veterinary Medicine, Stem Cell Research and Development Center, UniversitasAirlangga, Jl. Mulyorejo, Kampus C U

Published in the Indian Veterinary Journal September 2019 : 96 (09) - pages 14 to 16
(Received: February, 2019, Accepted: April, 2019)


Rabies is one of the zoonotic disease which exist in Indonesia. Vaccination using conventional seed is not capable to reduce the morbidity of rabies due to the unmatching between seed vaccine compared to circulating Rabies virus. Nine infected dog brain were collected from Sumatera, Sulawesi and Bali. They were processed into RT-PCR according to Glycoprotein encoding gene. Positive samples were processed into sequencing and molecular analysis. Epitopes of T and B cells were predicted. Two samples that were isolated from Sumatera showed high number of epitopes than others

Key Words: RABV, Epitope predictions, peptide vaccination.

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