Research Article | Animal Biotechnology

Biocomputational Analysis of Spike Proteins to Identify Evolutionary Divergence of Beta- CoVs with Focusing on SARS-CoV2

Hardeep Kaur, Yashpal Singh Malik and C.S. Mukhopadhyay

College of Animal Biotechnology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab, India

Published in the Indian Veterinary Journal December 2021 : 98 (12) - pages 22 to 29
(Received: , Accepted: )


Spike (S) proteins covering the outer surface of the Coronaviruses are the major hotspots of evolution and are also responsible for attaching the virus to the angiotensin-converting enzyme (ACE2) receptor on the host cells. In this study, we unveiled the evolutionary relics of the S-protein sequences of different beta Coronaviruses, namely, Severe Acute Respiratory Syndrome (SARS-CoV), SARS-CoV-2, and Middle East Respiratory Syndrome (MERSCoV).

Key Words: COVID-19, Angiotensin-converting enzyme (ACE2), spike proteins, severe acute respiratory syndrome.

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