Research Article | Animal Biotechnology
Biocomputational Analysis of Spike Proteins to Identify Evolutionary Divergence of Beta- CoVs with Focusing on SARS-CoV2Hardeep Kaur, Yashpal Singh Malik and C.S. Mukhopadhyay
College of Animal Biotechnology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab, IndiaPublished in the Indian Veterinary Journal December 2021 : 98 (12) - pages 22 to 29
(Received: , Accepted: )
Spike (S) proteins covering the outer surface of the Coronaviruses are the major hotspots of evolution and are also responsible for attaching the virus to the angiotensin-converting enzyme (ACE2) receptor on the host cells. In this study, we unveiled the evolutionary relics of the S-protein sequences of different beta Coronaviruses, namely, Severe Acute Respiratory Syndrome (SARS-CoV), SARS-CoV-2, and Middle East Respiratory Syndrome (MERSCoV).Key Words: COVID-19, Angiotensin-converting enzyme (ACE2), spike proteins, severe acute respiratory syndrome.