107/19 | Clinical & Field Article | Veterinary Pharmacology and Toxicology
Kaempferia galanga L. Inhibiting Effect on Vascular Endothelial Growth Factor (VEGF) and Cyclooxygenase-2 (Cox-2) Expression on Endothelium of Chorioallantoic Membrane
Iwan Sahrial Hamid, Juni Ekowati and Muhammad Thohawi Elziyad PurnamaDepartment of Veterinary Pharmacology, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya 60115, Indonesia
Published in the Indian Veterinary Journal September 2019 : 96 (09) - pages 80 to 82(Received: March, 2019, Accepted: May, 2019)
Abstract
This study was aimed to examine the extract of Kaempferia galanga L. to inhibit the expression of VEGF and Cox-2 on the chorioallantoic membrane of embryonated chicken eggs (ECE). This study used 24 ECE which were divided into six groups: (C+) inoculated with solvent, (C-, T1, T2, T3 and T4) inoculated with bFGF 60 ng then (T1, T2, T3 and T4) treated with the extract doses of 30, 60, 90 and celecoxib 60 mg, respectively. Expression of VEGF and Cox-2 was observed by the immunohistochemical method. It was concluded that the extract of Kaempferia galanga L. can inhibit the expression of VEGF and Cox-2 on the chorioallantoic membrane
Key Words: Kaempferia galanga L, VEGF, Cox-2, celecoxib