57/19 | General Article | Veterinary Anatomy and Histology

Multivalent Dengue Vaccines Induced Neutralization Antibodies in Rabbits

Lita Rakhma Yustinasari, Rahayu Ernawati, Fedik Abdul Rantam, and Agus Widodo

Department of Veterinary Anatomy, Faculty of Veterinary Medicine, Universitas Airlangga, Jalan Mulyorejo Surabaya, Indonesia 60115

Published in the Indian Veterinary Journal July, 2019 : 96 (7) - pages 10 to 11
(Received: February, 2019, Accepted: March, 2019)


Eighteen New Zealand White rabbits were vaccinated with multivalent dengue vaccines. The blood was collected on days 0, 7, 14, 21, and 28 and were examined using indirect ELISA. The positive results were cultured in vero cell (2x105 cell/well) that was infected with mixture of dengue antigen and antibody. The serum virus neutralization (SVN) result showed that antibodies were able to neutralize dengue virus and showed no cytopathic effect (CPE). It was concluded that multivalent dengue vaccines could induce neutralizing antibodies in rabbit.

Key Words: multivalent dengue vaccine, antibody, rabbits

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